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Although these therapeutic strategies are still in development, they have the potential to suppress ALS progression by directly targeting specified glial cell populations, applying Treg, and suppressing age-associated chronic inflammation ( Glial innate immunity in neurodegenerative diseases Early studies established that cytosolic DNA can elicit innate immune responses and innate inflammation, inducing type I interferons (IFNs), yet the molecular mechanism underlying this sensing remained unresolved (Seth et al., 2006)
Remember that peptides are a relatively new area of research and clinical use, and the understanding of their safety and efficacy is continually evolving
Since ceruloplasmin binds 85-95% of circulating copper and facilitates its safe transport, reduced synthesis means a higher fraction of "free" (non-ceruloplasmin-bound) copper in circulation
