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To increase the plasma half-life by avoiding renal elimination, GLP-1 analogs were modified by adding acyl groups (liraglutide and semaglutide) or large molecules such as albumin (albiglutide) and the Fc portion of IgG (dulaglutide)
In clinical practice, treatment may be guided by dominant cardiometabolic phenotype, with early combination therapy considered in individuals at high risk or with overlapping disease domains
For a 0.1 ml dose through a 30G needle, the full injection takes about 5-8 seconds
These injections are minimally invasive, non-surgical, and designed to produce subtle, natural results over time
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