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All experiments with mice were performed according to the protocols approved by the Committee of Animal Experiments of Osaka University (approval number 02-001-003), in accordance with the National Institutes of Health Guide for Care and Use of Laboratory Animals

Dehydration represents another plausible mechanism, especially in patients achieving significant weight loss

According to the existing data results, the clinical effect of these new drugs in research is better than that of simple GLP-1 agonists in terms of hypoglycemia and weight loss

For example, Borges et al

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