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Gastroenterology 132:21312157 Todd JF, Wilding JP, Edwards CM, Khan FA, Ghatei MA, Bloom SR (1997) Glucagon-like peptide-1 (GLP-1): a trial of treatment in non-insulin-dependent diabetes mellitus

For each of our 10 variable groups (Supplementary Table 5) we optimized xgboost models using fivefold cross-validation and two sequential hyperparameter grids searches with early stopping (972 different parameter combinations for each feature group in total) to predict mean-centered and unit variance-scaled (regularized) TMAO levels in the left-out group using root-mean-square error (RMSE) to evaluate model outcomes