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Fusions with the [G 4 S] 3 A linker to the antibody light chain displayed potent GLP-1R activation (EC 50 : 100300 pM) whilst PCSK9 binding activity decreased by 2-70-fold relative to the parental anti-PCSK9 antibodies
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The findings related to waist circumference related to a categorical weight loss of at least 5%, 10%, or 15% by week 26 of treatment administration
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