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J Diabetes Investig (2020) 11(2):2657
Sodiumglucose co-transporter 2 (SGLT2) inhibitors exert hypoglycaemic effects by inhibiting glucose reabsorption at the proximal convoluted tubules, causing glycosuria, natriuresis and volume contraction (Figure 1).5 Besides SGLT2 inhibition, incretin-based therapies have also been used in recent years for the treatment of T2D ( Figure 2 )
STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3
Glycemic optimization : Maintaining hemoglobin A1c below 7% (or individualized targets) may slow progression of diabetic complications affecting sexual function
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