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Of the four studies that assessed changes in Glx, three saw a decrease in the GABA/Glx ratio, a finding in line with our hypotheses described in section A Model for Changes in MRS Measured Glutamate, GABA, and Glutamine Levels During the Progression of ALS and above

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rhamnosus GG has been reported to increase intestinal FXR/FGF15 signaling, leading to decreased hepatic bile acid synthesis and prevention of excessive bile acid-induced liver injury and fibrosis in mice 60