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The gain in apparent affinity through avidity allows us to deliberately tune down the monomeric affinity of individual Fabs, mitigating on-target, off-tissue toxicities
That complex has a half-life of many hours, but the IGF-1 it carries is not free to bind IGF1R while complexed
The first actual incretin was described in 1973: glucose-dependent insulinotropic polypeptide, also known as gastric inhibitory polypeptide (GIP)
Patients need to be on the 2.4 mg maintenance dose for a minimum of four weeks before a provider can consider advancing to 7.2 mg
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