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As noted, endogenous GLP-1 has a very short half-life of 12 min because it is rapidly degraded by the enzyme DPP-4, which results in low systemic levels
Patients considering GLP-1 receptor agonist or dual GIP/GLP-1 therapy should understand that these medications facilitate weight loss through appetite reduction and decreased food intake, not by "speeding up metabolism" or burning additional calories at rest
4.6 Effect on neonatal necrotizing enterocolitis The protective effects of levocarnitine supplementation against hypoxia/re-oxygenic necrotizing enterocolitis (NEC) have been demonstrated in young mice (65)
10.1146/annurev-physiol-021115-105439 3
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