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However, the expression of GPx1 has been reported to be down-regulated in thyroid cancer [44], colorectal cancer [45, 46], and gastric cancer [47], whereas GPx1 has been demonstrated to play an oncogenic role in kidney cancer [48], pancreatic cancer [49], and laryngeal squamous cell carcinoma [50]
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However, if the kidneys are small, a biopsy is usually avoided due to risks like bleeding and less likelihood of finding a treatable condition
The peptide appeared to counteract L-NAME-induced hypertension while also reversing L-arginine-induced hypotension [8]
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