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Therefore, the GLP-1-induced excitation of MCs, probably via inhibition of voltage-dependent potassium channel conductance and enhancement of glutamatergic neurotransmission, could lead to changed excitability of higher olfactory cortical as well as hypothalamic regions to change metabolic states
Still, some meals may be more likely to feel heavy when appetite is low or stomach emptying is slower
However, tirzepatide also has low efficacy to induce GLP-1R internalisation, perhaps by its limited ability to recruit -arrestin
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