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Importantly, the researchers found no evidence that losing weight with these medications led people to become more physically active

The primary mechanisms driving weight reduction include: Delayed gastric emptying , which prolongs satiety and reduces appetite Central appetite suppression through effects on brain regions that regulate hunger Reduced caloric intake as a consequence of decreased appetite and early fullness Improved insulin sensitivity , which typically occurs secondary to weight loss and improved glycaemic control According to UK prescribing information, weight loss associated with Trulicity varies by dose, with greater mean weight loss observed at higher doses (3.0mg and 4.5mg)

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GLP-1 medications work by mimicking the bodys natural GLP-1 hormones that regulate blood sugar, insulin release, digestion, and appetite