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An outline of the MD simulations performed on the GLP-1R bound to Ex4-L-Ala ( a ), Ex4 ( b ) and Ex4-D-Ala ( c )

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For example, variants in the GLP1R pathway may correlate with differences in GLP-1 receptor expression or signaling efficiency, while FTO variants relate to obesity predisposition and metabolic risk

After matching, baseline characteristics between cohorts were well balanced in mean age (47.6 vs