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4A), and the results revealed an upregulation of IRE1 (an ER stress marker), indicating ER stress activation, reduced p62 levels, and increased LC3BII levels within 012 h of PFOS treatment
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Outcome measures include biomechanical testing (load to failure, stiffness), histological scoring (collagen organization, fibroblast density), and functional assessment (gait analysis, range of motion)
In summary, this outside-inside theory of skin dermatosis, which encompasses irritating chronic dermatitis, holds significant therapeutic implications [190]
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