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Biochim Biophys Acta (BBA)-Biomembranes (2013) 1828:134756
Stitely ML et al
As a general rule we would like the bottom lip to be one and a half times the size of the upper lip (or 40/60, upper to lower lip), though we can create other proportions, if the patient requests (a lip ratio of 1:1 is more popular in Latin America, and can create a beautiful, natural lip profile for many patients)
By inhibiting NNMT, it alters the balance of S-adenosylmethionine (SAM) and nicotinamide metabolism, affecting DNA methylation patterns and histone modifications
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