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The tumor uptake values of our PEGylated probe at 60-min post-injection in the resected organs of mice bearing INS-1 xenografts (Right thigh: 37.3 4.5%ID/g, Inside pancreas: 37.7 4.4%ID/g) showed comparable or higher values than those of other 18 F-labeled non-PEGylated modified exendin-4 probes
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Future iterations may achieve even higher bioavailability through improved SNAC technology or alternative permeation enhancers
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