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Timmermans notes that the patent for BPC-157 expired long ago, which means that no company presently has a clear profit motive to spend millions to fund human studies
Why Metabolic Safety Matters Full-length human growth hormone therapy carries well-documented metabolic risks including IGF-1 elevation, impaired glucose tolerance, and increased diabetes risk
They make sense conceptually but need clinical trials to determine safety, dosage, timing and interactions
Some patients experiment with twice-weekly dosing, but published data doesn't support additional benefit
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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