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Larger sample sizes are crucial to account for baseline imbalances between study groups and to better elucidate the specific impact of GLP-1 receptor agonists on both the symptoms and progression of PD

Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

Tregs themselves are vital in peripheral immune tolerance and suppressing autoimmunity and inflammation through control of adaptive and innate immune responses (Johnson et al., 2018)