Retatrutide is a synthetic peptide that acts as a triple agonist of the GCG-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and GCG receptors
This reduction indicates lower immune activation and diminished neuroinflammatory stress, which are critical in slowing Alzheimer's progression
Alterations in key metabolic pathways such as glycolysis and oxidative phosphorylation profoundly affect the activation, differentiation and function of B and T cells, monocytes, neutrophils and other immune cells, driving inflammation and tissue injury
( d ) Side view and ( e ) top view of GLP-1R bound to Ex-P5, Chu-128 and Ex-4-D-Alas two conformers shown in cyan, brown, blue, and orange, respectively