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Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors, distinguishing it from dual agonists like tirzepatide and single agonists like semaglutide
Altogether, we find that LPC induces a more acute and sustained microglial response characterized by PVM recruitment, increased proliferation, persistent DAM enrichment, and broader inflammatory gene activation
semaglutide mimics this to aid in diabetes and weight loss
Common side effects such as nausea, vomiting, and food aversions can further reduce intake, increasing this risk
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