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Liver fibrosis positive area reduced compared to the Vehicle group (Figure 8D)
Principal coordinate analysis (PCoA) showed that overall, the gut microbial community was significantly modified by CB0313.1, with all the HF diabetic mice exhibiting a dramatic shift along the same direction, while CB0313.1 could reverse the diabetes-induced variations along the first principal component (PC1) (Fig
SGLT2i have shown robust effects in reducing heart failure hospitalization and slowing the progression of chronic kidney disease, while GLP-1 RAs have demonstrated superior efficacy in reducing atherothrombotic events, particularly non-fatal stroke
