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Some studies have explored treatments for cancer aimed at altering IGF-1 activity, but more research is needed
The result is that GH release remains pulsatile and self-regulated the pituitarys natural feedback mechanisms prevent GH from rising to levels that cause the side effects common with exogenous HGH (edema, carpal tunnel, joint pain, elevated fasting glucose)
Therefore, understanding the endogenous expression profile of IGF-1 during tendon healing is crucial for determining the optimal timing of exogenous IGF-1 administration
Conchillo M, de Knegt RJ, Payeras M, Quiroga J, Sangro B, Herrero JI, Castilla-Cortazar I, Frystyk J, Flyvbjerg A, Yoshizawa C: Insulin-like growth factor I (IGF-I) replacement therapy increases albumin concentration in liver cirrhosis: results of a pilot randomized controlled clinical trial
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