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It does not dry up milk
Because the liver is the primary site of IGF-1 synthesis and a major organ of peptide metabolism, hepatic function directly shapes both the downstream effect of GH stimulation and the clearance of the drug itself
Nucleic acids research
In summary, genetic loss of PTPN11 caused deeper metabolic and signaling rewiring than pharmacologic inhibition did, likely due to clonal selection and/or the complete loss of phosphatase-independent molecular adapter functions of SHP2, and may not reflect the phenotype induced by allosteric inhibition
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