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Other factors, including patient age, gender, body mass index (BMI), and hepatitis C infection, further exacerbate the risk of PTDM. Current management of PTDM remains a challenge, often requiring adjustment immunosuppressant regimens and promoting lifestyle changes

It is synthesised in the cytosol by glutamate-cysteine ligase (EC 6.3.2.2) and glutathione synthetase, with the first, rate-limiting step feedback-inhibited by glutathione itself and intracellular concentrations typically 1 to 8 mM (Griffith, Free Radical Biology and Medicine, 1999)

Some medications may be subject to restrictions, such as prior authorization or step therapy requirements