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The search covered databases including PubMed, MEDLINE, Embase, Web of Science, and Reprotox, from their inception through January 2026, along with references from qualifying studies
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In addition, Astragaloside IV treatment increased the phosphorylation of PI3K and Akt to promote the restoration of NRF2 expression and nuclear translocation [220]
Clinical studies have measured improvements in skin firmness of 20-30% after 12 weeks of topical GHK-Cu treatment
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