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The recombinant SGLs-Exendin-4-Fc plasmid was verified by DNA sequencing (forward primer: 5-CAGGACCACGTCGTGCCAGT-3)

At least 27 new GLP-1 drugs are currently undergoing trials at various stages, including a triple-hormone-receptor agonist combining GLP-1, GIP and glucagon receptors

Additional mechanistic work, such as what has been described, the interdependence between sphingolipids, steroids, and specific microbial-derived metabolites provides another approach to identify biologically relevant metabolite ratios 65,66,67 that then may be studied further via targeted assays