These improvements in glucose metabolism directly reduce the hyperinsulinemia that drives many PCOS symptoms
Prokisch H, Scharfe C, Camp DG, 2nd, Xiao W, David L, Andreoli C, Monroe ME, Moore RJ, Gritsenko MA, Kozany C, Hixson KK, Mottaz HM, Zischka H, Ueffing M, Herman ZS, Davis RW, Meitinger T, Oefner PJ, Smith RD, and Steinmetz LM
Doxorubicin and vincristine treatment upregulates the expression of S100A8, which is required for the formation of the Beclin1III phosphatidylinositol 3-kinase (PI3KC3) complex [98]
These typically emerge during dose titration and often diminish over several weeks