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Taken together, we propose that chronic GSH depletion induces redox activation of the AMPK pathway that may serve as the central link triggering mechanisms that prevent alcohol-induced liver injury (as illustrated in Fig

These results suggest that the decline in glutathione in neurons is more critical for the brain atrophy than that in astrocytes

A comprehensive review of free radicals, oxidative stress, and antioxidants: overview, clinical applications, global perspectives, future directions, and mechanisms of antioxidant activity of flavonoid compounds

It is worth noting that while the aforementioned studies have validated the efficacy of nanomaterials in inhibiting NLRP3 inflammasome-mediated pyroptosis, systematic comparisons of their specific intervention targets at different stages remain lacking