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Their Cryo-TEM images show uniformly distributed liposomes in multiple configurations: unilamellar (single-layer), multilamellar (multiple layers), and multivesicular (compartmentalized internal structures)

doi: 10.1016/j.bbi.2012.02.008 424 BalinasCEaton-FitchNMaksoudRStainesDMarshall-GradisnikS

8 A case-control study that compared 25,956 patients who had vitamin B 12 deficiency with 184,199 control patients found a significantly increased risk of vitamin B 12 deficiency in patients who had taken proton pump inhibitors (odds ratio = 1.65) or histamine H 2 blockers (odds ratio = 1.25) for at least two years

That is not always obvious at the time, which is why dose and schedule should be set against a confirmed clinical picture rather than guesswork