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although its chemical activity is similar to the original drug, MTX-PG 2-6 is preferentially kept in the intracellular environment [whereas non-glutamylated MTX is quickly exported by ABC transporters ( MTX primarily acts by inhibiting dihydrofolate reductase (DHFR), which catalyzes the sequential conversion of folic acid to dihydrofolate (DHF) and tetrahydrofolate (THF)
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Merad-Boudia M, Nicole A, Santiard-Baron D, Saille C, Ceballos-Picot I
This cruciferous wonder promotes a robust antioxidant defense system in your body, enabling it to combat oxidative stress effectively
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