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The full benefits of the medication may be observed after 6-12 months of consistent use

This article explores the mechanisms behind taste alterations, common patient experiences, and practical strategies for navigating these changes during GLP-1 therapy

Common side effects during the adjustment period (typically the first 24 weeks): Mild nausea usually less intense than when first starting a GLP-1 medication Changes in appetite (some patients notice less appetite suppression early on at the starting 0.25 mg dose) Mild stomach discomfort, bloating, or constipation Injection site reactions Side effects that are less likely during the switch (compared to first-time GLP-1 use), but still possible: Significant vomiting less common given prior GLP-1 exposure, but possible Hypoglycemia particularly relevant for type 2 diabetes patients on insulin or sulfonylureas

If they bloat you, pull back and try again in smaller amounts later