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However, percentage weight loss tends to be relatively similar across starting weights, meaning someone starting at 200 pounds and someone starting at 300 pounds may both lose roughly 15% by 68 weeks, even though the absolute numbers differ dramatically

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[1] [2] Unlike phentermine's central nervous system stimulation, tirzepatide works through multiple mechanisms: it enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite through central pathways