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The overall side effect profile is broadly similar to, though not identical to, that of semaglutide alone
Quality of Life Improvements Depression scores from the HAD scale showed significant improvement: The mean increase in depression score was 0.8 for the GSH group compared to 2.5 in the control group (P = 0.015)
Methods Electronic databases, Medline and Embase were reviewed for randomized trials from inception to 29 May 2025
GLP-1 receptors are present in the brains dopamine reward pathways (van Bloemendaal et al., Diabetes Obes Metab, 2014)
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