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A temporary plateau (two to four weeks where weight fluctuates within a small range due to water retention, hormonal shifts, or muscle gain) differs from a true plateau, where weight and body composition remain unchanged for eight weeks or more
Whether retatrutide reduces heart attacks and strokes remains an open question, and answering it is the job of the separate dedicated cardiovascular outcomes trial, which is much larger and still running
This is due to possible bacterial contamination and reduced potency over time
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