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Regulatory note: FOXO4-DRI is not FDA- or EMA-approved for human use
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Understanding how these three signalling axes interact is central to current metabolic research and forms the primary basis for ongoing investigational study of this compound
To control that this basal activity is really mediated by MRP1, we mutated in MRP1 WT a cluster of 6 residues that were proven to be involved either in GSH binding or transport, R1138, R1142 38 , S1252, E1253 39 , or in binding of the GSH moiety of LTC 4 , R1249 and N1245 40
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