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But for some people, that slower emptying can lead to uncomfortable symptoms like nausea, bloating, or even gastroparesis , a condition where food moves through the stomach more slowly than it should (Al-Aly et al., 2025
How much it costs: The retail cost of brand-name Ozempic is high, around $1,000
The first replaces the amino acid alanine at position 8 with 2-aminoisobutyric acid (Aib), making the molecule resistant to cleavage by the enzyme dipeptidyl peptidase-4 (DPP-4), which rapidly inactivates natural GLP-1
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