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This finding indicates that epigenetic variation, which may well be susceptible to contextual and other environmental influences, has a greater effect on serum UA than the identified genetic factors and certainly deserves further investigation in PD

Frontiers in Cellular and Infection Microbiology, 12, 915701

However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]

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