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When kidney perfusion drops, the risk of acute kidney injury (AKI) increases, especially in dehydrated patients

Besides, only in a minority of patients, elevation of pancreatic or liver enzymes was seen, resulting in no pancreatitis and/or cholelithiasis occurrence, which was also verified in a recent meta-analysis showing that treatment with GLP-1-RAs is not associated with increased risk for acute pancreatitis, renal failure, or malignant neoplasms [43]

Dopo ulteriori studi, la semaglutide stata riformulata con una dose pi alta e approvata dalla FDA nel 2021, e pi di recente dallEMA in Europa e lAIFA in Italia, come Wegovy per il trattamento dellobesit