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They found a half-life of under 30 minutes post-injection, with bioavailability after intramuscular administration at 14 to 19 percent for rats and 45 to 51 percent for dogs

High strength gives rapid results but comes at high cost

Natural mast cell stabilizers like quercetin, fisetin, and luteolin can reduce histamine release

Common gastrointestinal side effects occur in many patients and include: Nausea (most common, typically improving after 4-8 weeks) Vomiting Diarrhea Constipation Abdominal pain or discomfort Decreased appetite These effects result from the drugs' mechanism of actionslowing gastric emptying and affecting gut motilityrather than indicating tissue damage or malignancy