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These medications may not be appropriate for individuals who: Are pregnant or planning pregnancy Are breastfeeding Have a history of pancreatitis Have severe gastrointestinal disorders Have certain thyroid conditions Healthcare providers will review medical history and current medications to determine suitability

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Conversely, Hantson and coworkers [83] recently reported the case of a 47-year-old epileptic man in whom parenteral VPA therapy was associated with a severe hyperammonaemic encephalopathy (peak ammonia concentration 411 mol/l) without any biological signs of hepatotoxicity

doi: 10.1016/j.ejmech.2015.04.040 18 SharafADe MicheleRSharmaAFakhariSObornikM