42 Planks: Strengthens core muscles
Metformin inhibits TGF-1-induced epithelial-mesenchymal transition and liver metastasis of pancreatic cancer cells
For a drug protected across Germany, France, Italy, Spain, the Netherlands, and Switzerland, the combined annual European annuity payments for a single patent can reach EUR 15,000 to EUR 25,000 in mid-life, rising further in later years
For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results