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This overlap is better understood within a broader framework of polyautoimmunity: autoimmune thyroid disease is one of the most frequent components of overt or latent polyautoimmunity, while CD may also appear within autoimmune polyendocrine or polyautoimmune clusters

The distinguishing feature of Asp is its acidic side chain (CHCOOH), which also exists predominantly in the deprotonated form (CHCOO) under physiological conditions, thereby contributing a negative charge