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Optimal grids for AMYR:Cagri complexes and CTR: Cagri ( N = 1) were imaged by conventional cryo-TEM on a Thermo Fisher Scientific Titan Krios microscope operated at an accelerating voltage of 300 kV with a 50 m C2 aperture and a 100 m objective aperture at an indicated magnification of 105kx in nanoprobe EFTEM mode, yielding a calibrated pixel sampling of 0.85 .pix -1

Clinical Trial Design for Accelerated Drug Approval Despite the exciting potential for GLP-1 drugs to treat a range of conditions beyond obesity and diabetes, obtaining drug approval for new indications for use remains a daunting task due to the considerable time, effort, and resources required to conduct the necessary clinical trials

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Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis