However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig
Without this information, values from different studies may not be directly comparable
This is where Epitalon steps into a more subtle but powerful role: modulating gene expression by physically interacting with DNA and chromatin structures
Of course, our other recommendations also let you titrate as needed, but to potentially less effect