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These gastrointestinal issues are usually temporary and may decrease as your body adjusts to the medication

A 2022 cohort study analyzed weight loss outcomes in 175 people with obesity or overweight who were taking 1.7 mg or 2.4 mg of semaglutide for six months

Human clinical trial data is limited, which is common across the peptide landscape

Conservative treatment approaches Physical activity and rehabilitation: Regular physical activity reduces proinflammatory adipokines and macrophages and improves blood flow, thereby counteracting hypoxia in adipose tissues.24 Exercise routines should be tailored to individual needs and ideally supervised by qualified health professionals.12 Beneficial exercises which should start slowly and progress as tolerated include swimming, aquatic therapy, elliptical machines, yoga, stationary biking, whole-body vibration, and walking.15 The goals of physical activity are weight control, improved muscle strength and mobility, and enhanced self-esteem.20 Special diets: Since lipedema is considered a polygenic disorder associated with chronic low-grade inflammation, some authors recommend anti-inflammatory diets such as the Mediterranean or ketogenic diet to reduce symptoms.37 Dietary management should prioritize reducing hyperinsulinemia and insulin resistance