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36 , 130143 e135 (2024)
According to a study by the Global Burden of Disease, 7.74 million people were living with sickle cell disease in 2021
In TRIUMPH-4, the higher-dose arms saw discontinuation due to side effects of around 12% to 18%, though some of that was linked to baseline weight and to perceived excessive weight loss rather than intolerance alone
Most patients notice reduced appetite within the first week and see measurable weight loss within 2-3 weeks
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