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Approximately 25% of all diabetics suffer from peripheral neuropathy, where a partial dissolution of the myelin layer, which encloses the nerve fibers, is indicated
On mechanism, the peptides and the small molecules end up at the same destination (Gs activation, cAMP elevation, the canonical incretin pharmacology) but they get there via different binding modes and with different signalling profiles
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doi:10.2337/db15-1255 17
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