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Protein components This category includes both cytoplasmic and membrane-associated proteins, such as receptors, enzymes, transcription factors, ECM proteins, and MHC proteins [70] (Fig

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Caspase-1 cleaves gasdermin D (GSDMD), whose N-terminal fragment forms pores in the plasma membrane, leading to cell lysis and the release of proinflammatory cytokines such as interleukin 1 beta (IL1B), IL-18, and IL1A [70]