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Where once Rybelsus stood alone as the only GLP-1 pill available, patients and clinicians must now navigate three distinct oral products, each with a different molecule, a different approved indication, and a different set of practical requirements
Rare but serious side effects include pancreatitis , thyroid cancer , and kidney damage
The new figure reflects trends influencing how these drugs are priced, how long patients stay on them, and how patient populations are segmented, says Asad Haider, head of the healthcare business unit within Goldman Sachs Research
The mechanisms of action are fundamentally different: GLP-1 agonists are synthetic or modified peptides designed to mimic incretin hormones and directly stimulate specific cellular receptors, while allulose is a simple sugar that undergoes passive absorption and excretion
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