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Physiologically, this lowering of GSH led to increased LDH release ( P = 0.031), consistent with redox activation of ferroptosis and cell death (Figure 4C and refs
However, the sample size in that study was small, as only 16 rats (eight per group) were used in their experiment, and the study duration was short (11 days), which may have affected the statistical significance and generalizability of the results
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